CONTACT

Enrolling trials 

The trials below are currently Accepting new patients for participation. If you are interested in particpating in one of our enrolling clinical trials, please call 512-279-1251.

Wet Age-Related Macular Degeneration

  • Opthea OPT-302-1002– A Phase II, dose-ranging study of intravitreal OPT-302 in combination with ranibizumab compared to ranibizumab alone in patients with neovascular age-related macular degeneration

  • Graybug GBV-102-001– A Phase I/II, multicenter study evaluating the safety, tolerability, and efficacy of an intravitreal depot formulation of Sunitinib Malate (GB-102) in subjects with neovascular age-related macular degeneration
  • Iconic IT-004 - A Phase 2 randomized, open-label, multicenter study evaluating administration of repeated doses of ICON-1 in patients with choroidal neovascularization secondary to age-related macular degeneration
  • Santen 36-002 Avante - A multi-center, randomized, double masked and active controlled Phase II study assessing the safety and efficacy of intravitreal injections of DE-122 in combination with Lucentis compared to Lucentis monotherapy in subjects with wet age-related macular degeneration

Dry Age-Related Macular Degeneration

  • University of Virginia TOGA (Treatment with Oracea for Geographic Atrophy) - A Phase III study to evaluate the efficacy of daily administration of ORACEA®, a tetracycline derivative approved for treatment of inflammatory lesions of rosacea in adults, compared to placebo on the rate of change of geographic atrophy in patients with dry age-related macular degeneration

Proliferative Diabetic Retinopathy

  • None enrolling at this time.

Non-proliferative Diabetic Retinopathy

  • Boehringer-Ingelheim 1386.12 Robin - A Phase II, double-masked, placebo-controlled, study to evaluate the safety and tolerability of oral BI 1467335 in patients with moderate to severe non-proliferative diabetic retinopathy

Diabetic Macular Edema

  • DRCR Protocol AC - Aflibercept versus bevacizumab + deferred aflibercept for treatment of center-involved diabetic macular edema.
  • Kalvista KVD001-201 - A randomized sham-controlled double-masked Phase 2a study of the efficacy, safety and tolerability of the intravireal plasma kalikrein inhibitor, KVD001, in subjects with center-involving diabetic macular edema who have had prior anti-VEGF treatment

Retinal Vein Occlusions

Macular Telangiectasia Type II

  • The Macular Telangiectasia Project- A natural history, observation, and registry study of macular telangiectasia type 2
  • Neurotech NTMT-03 - A Phase III, sham-controlled study to determine the safety and efficacy of Renexus in macular telangiectasia type 2.

Closed Enrollment

The trials below are open, but are No Longer Accepting new patients for participation.  Please continue to check our website for the next phase of these exciting trials. 

  • Aerpio Therapeutics AKB-9778-CI-5001 -  A Phase II  study assessing the safety and efficacy of subcutaneously administered AKB-9778 15mg once daily or 15mg bid for 12 months  compared to placebo in patients with moderate to severe non-proliferative diabetic retinopathy
  • DRCR Protocol W - Intravitreous Anti-VEGF Treatment for Prevention of Vision Threatening Diabetic Retinopathy in Eyes at High Risk
  • Genentech GX28228 OAT Sub-Study– Oral antithrombotic therapy substudy in association with study GX28228: A Phase II,  randomized, active treatment-controlled study of the efficacy and safety of the ranibizumab port delivery system for sustained delivery of ranibizumab in patients with subfoveal wet AMD
  • Daiichi DS7080a (DME) -  Phase I study of intravitreal 4.0mg DS7080a compared to Lucentis in subjects with diabetic macular edema.
  • DRCR Protocol AB -  Intravitreous  Anti-VEGF vs. Prompt Vitrectomy for Vitreous Hemorrhage from Proliferative Diabetic Retinopathy
  • Regeneron Panorama - A Phase 3, randomized study of the efficacy and safety of intravitreal aflibercept injection in patients with moderate to severe non-proliferative diabetic retinopathy.
  • Acucela 4429-203 - Randomized, double-masked, placebo-controlled, pilot study to evaluate the effects of Emixustat Hydrochloride on aqueous humor biomarkers associated with PDR.

  • Santen Inc. 36-001 PAVE  A Phase I/II, open-label, dose escalating, sequential-cohort study assessing the safety, tolerability, immunogenicity and bioactivity of a single intravitreal injection of DE-122 in refractory wet ARMD patients
  • Genentech BP29647 AVENUE  –A Phase II study evaluating the safety, tolerability, pharmacokinetics  and efficacy of RO6867461 compared to Lucentis  in subjects with wet ARMD
  • Daiichi Sankyo Pharma DS7080-A-U101 - A Phase I, dose escalation and expansion study of DS-7080a in subjects with neovascular ARMD
  • Tyrogenex, Inc. X-82-OPH-201 - A Phase IIb study of oral X-82 plus PRN Eylea compared to PRN Eylea monotherapy in subjects with  neovascular ARMD
  • Regeneron R910-3-AMD-1517 ONYX A Phase II, randomized, double-masked, active controlled, study of the efficacy, safety and tolerability of repeated doses of intravitreal REGN910-3 in patients with neovascular ARMD
  • Genentech Chroma - A Phase III study evaluating  the efficacy and safety of Lampalizumab administered intravitreally to patients with geographic atrophy secondary to ARMD
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol S- To Determine if Vision Outcome at Two Years in Eyes with PDR (with or without concurrent DME) that Receive Anti-VEGF Therapy with Deferred PRP are Non-Inferior to Those in Eyes that Receive Standard Prompt PRP Therapy
  • Apellis Pharmaceuticals Inc. FILLY - A Phase II, randomized, single-masked, sham-controlled study of safety, tolerability and evidence of activity of intravitreal APL-2 therapy  in subjects with geographic atrophy secondary to ARMD 
  • DRCR Protocol U - A short-term evaluation of combination corticosteroid + Anti-VEGF treatment for persistent diabetic macular edema following Anti-VEGF therapy in pseudophakic eyes. 
  • DRCR Protocol V - A study to compare the safety and efficacy of (1) prompt focal/grid  photocoagulation + intravitreal Eylea, (2) observation + deferred intravitreal Eylea, and (3) prompt intravitreal Eylea in eyes with central-involved diabetic macular edema and good visual acuity.
  • Genentech BP30099 BOULEVARD –A multi-center, multi-dose, randomized, active comparator-controlled , double-masked 28 week study to investigate the safety, tolerability, pharmacokinetics and efficacy of RO6867461 administered intravitreally ion patients with DME.
  • Alimera Sciences Inc. Paladin - A Phase IV safety study of IOP signals in patients treated with Iluvien 0.19mg

Closed trials

The trials below are trials we have participated in, the investigational data has been collected by the pharmaceutical companies sponsoring the trials, and those companies have moved the drugs to the next stage of development for the particular medication in question. These trials do not have any active participants. We maintain an updated list of these trials for educational and academic purposes.

  • Abbott: M327 - A Multicenter Open-Label Study of the Long-term Safety and Efficacy of the Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects with Non-infectious Intermediate, Posterior, or Pan-uveitis
  • Abbott: M877 - A Multicenter Study of the Efficacy and Safety of the Human Anti-TNF Monoclonal Antibody Adalimumab as Maintenance Therapy in Subjects Requiring High Dose Corticosteroids for Active Non-infectious Intermediate, Posterior, or Pan-uveitis
  • Abbott: M880 - A Multicenter Study of the Efficacy and Safety of the Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects with Inactive Non-infectious Intermediate,Posterior, or Pan-uveitis
  • Aciont, Inc.  DSPV-201 -  A randomized, parallel group, double-masked, active-controlled Phase1/2 clinical trial to evaluate the efficacy and safety of dexamethasone sodium phosphate Visulex system for the treatment of non-infectious anterior uveitis
  • Acucela: 4429-201 - Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACU-4429 in Subjects With Geographic Atrophy
  • Acuity: (CARE) - A Phase II, Randomized, Double-Masked, Controlled, Dose Comparison Study of Cand5 for Intravitreal Injection for the treatment of Subfoveal Choroidal Neovascularization associated with Wet Age-Related Macular Degeneration
  • Aerpio: A Phase 2, Randomzied, Active-Controlled, Double-Masked, Multi-Center Study to Assess the Safety and Efficacy of Daily Subcutaneous AKB-9778 Administered for 3 Months, as Monotherapy of Adjunctive to Ranibizumab, in Subjects with Diabetic Macular Edema
  • Alcon: C-10-034 - A Phase 3 Multicenter, Randomized, Double-Masked Study of the Safety and Efficacy of Difluprednate 0.05% Ophthalmic Emulsion Compared to Prednisolone Acetate 1% Ophthalmic Suspension in the Treatment of Endogenous Anterior Uveitis
  • Alcon: C-04-18 - Clinical Evaluation of the Safety of Next Generation Ophthalmic Irrigation Solution Compared to BSS PLUS® for Use During Surgery for Removal of Epimacular Membrane and Vitrectomy
  • Alcon: C-09-067 (Race) - Controlled, Double-Masked, Randomized, Multicenter Study to Evaluate AL-78898A as a Treatment of Exudative AMD
  • Alcon (C13001): A Prospective, Two Cohort, Single-Masked Study to Evaluate the Effect of ESBA1008 Applied by Microvolume Injection or Infusion in Subjects With Exudative Age-Related Macular Degeneration
  • Alcon (OWL) - ESBA1008 Microvolume Study
  • Alimera: C0105001 (FAME)- Fluocinolone Acetonide Implant Compared to Sham Injection in Patients With Diabetic Macular Edema
  • Allergan: 206207-008 (RVO) - Dexamethasone PS DDS versus Placebo in a 3-year study for treatment of Retinal Vein Occlusions
  • Allergan: 206207-011 - A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema
  • Allergan (REACH): Multiple Dose of the Safety and Efficacy of AGN-150998 in Patients with Exudative Age-Related Macular Degeneration
  • AMPIO Pharmaceuticals (Optina): A Randomized, Placebo-Controlled, Parallel, Double-Masked Study to Evaluate the Efficacy and Safety of Two Doses of Oral Optina in Adult Patients With Diabetic Macular Edema
  • Athenagen: ATG003-201 - Mecamylamine HCL ophthalmic solution versus placebo in the treatment of Neovascular Age Related Macular Degeneration (wet)
  • Athenagen: ATG003-203 - Safety and Efficacy of ATG003 in Patients with AMD Receiving Anti-VEGF
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol A - A Pilot Study of Laser Photocoagulation for Diabetic Macular Edema
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol B - Intravitreal triamcinolone acetonide versus laser in the treatment of Diabetic Macular Edema
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol D - Post-vitrectomy long-term assessment
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol H - Assessment of Avastin for the treatment of Diabetic Macular Edema
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol I - Intravitreal Ranibizumab or Triamcinolone Acetonide in Combination with Laser Photocoagulation for Diabetic Macular Edema
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol J - Intravitreal Ranibizumab or Triamcinolone Acetonide as Adjunctive Treatment to Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol M- Effect of Diabetes Education during Retinal Ophthalmology Visits on Diabetes Control
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol N- An Evaluation of Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol O - Comparison of Time Domain OCT and Spectral Domain OCT Retinal Thickness Measurement in Diabetic Macular Edema
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol P - A Pilot Study in Individuals with Center-Involved DME Undergoing Cataract Surgery
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol Q - An Observational Study in Individuals with Diabetic Retinopathy without Center-Involved DME Undergoing Cataract Surgery
  • Diabetic Retinopathy Clinical Research (DRCR): Protocol T: A comparative study of intravitreal aflibercept, bevacizumab, and ranibizumab for diabetic macular edema
  • Endo Pharmaceuticals: EN3324-201 - Efficacy and Safety of EN3324 in Subjects With Chronic Low Back Pain (CLBP)
  • Eyetech: EOP1023 (LEVEL) - Macugen maintenance therapy in Macular Degeneration
  • Genaera: MSI-1256-301 - A Phase 3 Multicenter, Randomized, Double-Masked, Controlled Study of Squalamine Lactate (MSI-1256F) for Injection for the Treatment of Subfoveal CNV associated with Age-Related Macular Degeneration.
  • Genentech: FVF2587g (ANCHOR) - Phase III research trial evaluating Rhu Fav v2 vs. Visudyne therapy in Classic Subfoveal Macular Degeneration
  • Genentech: FVF4165g (BRAVO) - A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Branch Retinal Vein Occlusion
  • Genentech: FVF4166g (CRUISE) - A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Central Retinal Vein Occlusion
  • Genentech: FVF4170g (RISE) - A Study of Ranibizumab Injection in Subjects With Clinically Significant Macular Edema With Center Involvement Secondary to Diabetes Mellitus 
  • Genentech: CFD4870g (MAHALO)- Controlled Study of Safety, Tolerability, and Evidence of Activity of FCFD4514S Intravitreal Injections Administered Monthly or Every Other Month to Patients with Geographic Atrophy
  • Genentech: FVF3426g (HORIZON) - Lucentis Treatment of CNV in Wet Age Related Macular Degeneration
  • Genentech: FVF3426g (HORIZON) - Extension to BRAVO and CRUISE; the use of Lucentis in patients with macular edema secondary to branch and central retinal vein occlusion
  • Genentech: FVF3869g (SAILOR) - Evaluating the Safety and Tolerability of Ranibizumab (Lucentis) in Naïve and Previously Treated Subjects with Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
  • GlaxoSmithKline (BAM114311) - A Phase 2 Study to Investigate GSK933776 in Adult Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration 
  • GlaxoSmithKline: MD7108240 - A Study to Evaluate the Pharmacodynamics, Safety, and Pharmacokinetics of Pazopanib Drops in Adult Subjects With Neovascular AMD
  • GlaxoSmithKline: OUTCOME - PRACTICE Study: Study Manual and Chart Abstraction
  • GlaxoSmithKline: FFR110537 - A Clinical Study With Fluticasone Furoate Nasal Spray And Vehicle Placebo For The Treatment Of Perennial (Year-round) Allergic Rhinitis
  • GlaxoSmithKline: MD7114987 - To Evaluate Pazopanib Eye Drops Administered for 12 Weeks to Patients with Neovascular Age Related Macular Degeneration
  • Grunenthal: KF0151Y/10 - NUCYNTA (Tapentadol Immediate Release) Versus Oxycodone Immediate Release in the Treatment of Acute Low Back Pain
  • iCO Therapeutics and Juvenile Diabetes Foundation (iDEAL Study): A Randomized, Multi-center, Phase II Study of the Safety, Tolerability and Bioactivity of Repeated Intravitreal Injections of iCo-007 as Monotherapy or in Combination with Ranibizumab or Laser Photocoagulation in the Treatment of Diabetic Macular Edema with Involvement of FoveAL Center
  • LPath LT1009-Oph-002 (PEDigree) - Phase 1B Multi-Center Blinded and Randomized Study of iSONEP Administered as Intravitreous Injections to Subjects with PED Secondary to Exudative Age-Related Macular Degeneration
  • Lpath (Nexus): A Phase IIA study of iSONEP as monotherapy or adjunctive therapy to Lucentis or Avastin versus Lucentis or Avastin alone for treatment of patients with choroidal neovascularization secondary to age-related macular degeneration  
  • LuxBiosciences: LX21101, LX21102, LX21103 (LUMINATE) - The assessment of LX211 in the treatment of active and quiescent anterior, posterior, intermediate, and pan non-infectious uveitis 
  • LUX 211-11- A Multi-center, Double-Masked, Parallel Group, Placebo-Controlled Study to Assess the Efficacy and Safety of Voclosporin as Therapy in Subjects with Active Noninfectious Intermediate, Posterior or Pan-uveitis 
  • Macusight: DR-002 (DIAMOND) - Dose Ranging Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Diabetic Macular Edema
  • Macusight: AMD-003 (EMERALD) - Phase 2 Study of an Ocular Sirolimus (Rapamycin) Formulation in Combination With Lucentis® in Patients With Age-Related Macular Degeneration
  • Molecular Partners: MP0112-CP02 - Study of MP0112 Intravitreal Injection in Patients with Diabetic Macula Edema 
  • NeoVista: NVI-114 (CABERNET) - A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration
  • Novartis: CAEB071A2211 - Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis
  • Novartis: CBPD952A2308 (DENALI) - Lucentis monotherapy versus Lucentis + Visudyne in the treatment of naïve patients with Neovascular Age Related Macular Degeneration (wet)
  • Novartis: CBPD952E2202 (VERITAS) - Laser with Visudyne plus triamcinolone acetonide versus Visudyne plus Macugen in patient with Subfoveal Chorodial Neovascularization secondary to Age Related Macular Degeneration (wet)
  • Novartis: CBPD952E2201 (VisTA) - A Randomized Trial to evaluate the effect of photodynamic therepy using Visudyne in combination with intravitreal injection of Triamcinolone Acetonide in Occult Subfoveal and Minimally Classic Subfoveal Choroidal Neovascularization secondary to Age-Related Macular Degeneration
  • Novartis CCLG561-2201 - A proof-of-concept study of  intravitreal CLG561 as a monotherapy or in combination with LFG316 in subjects with geographic atrophy secondary to ARMD
  • Ophthotech (Fovista): A Phase 3 Randomized, Double-Masked, Controlled Trial to establish the safety and efficacy of intravitreous administration of FOVISTA(TM) administered in combination with Lucentis compared to Lucentis monotherapy in subjects with subfoveal neovascular age-related macular degeneration 
  • OPKO: ACU-301 (COBALT) - Intravitreal bevasiranib administered every 8 or 12 weeks as maintenance following Lucentis versus Lucentis monotherapy every 4 weeks.
  • Pfizer: A3921034 - A Prospective, Randomized, Placebo and Active Comparator Controlled Study of CP-690,550 in Subjects with Dry Eye
  • Pfizer: B0451001 (MONET)- Phase II Open Label Multicenter Study For Age Related Macular Degeneration Comparing An Investigational Drug PF-04523655 Versus Lucentis In The Treatment Of Subjects With Choroidal Neovascularization 
  • Pfizer: B1181002- Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy
  • Pfizer (B1181003) - A Phase II Study evaluating dosages of RN6G in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration
  • Pfizer (B1261009): A Phase 2, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist With Ranibizumab In Adults With Diabetic Macular Edema 
  • Regeneron: VGFT-OD-0706 Da Vinci- An Open-Label, Long-Term, Safety, and Tolerability Study of Intravitreal VEGF Trap in Subjects with Neovascular Age-Related Macular Degeneration
  • Quark (Matisse): An Open-Label Dose Escalation Study of PF-04523655 (Stratum I) Combined With A Prospective, Randomized, Double-Masked, Multi-Center, Controlled Study (Stratum II) Evaluating The Efficacy and Safety of PF-04523655 Alone and in Combination with Ranibizumab Versus Ranibizumab Alone in Diabetic Macular Edema
  • Regeneron: VGFT-OD-0603 (Clear-IT 1b) - Repeated doses of intravitreal administration of two VEGF Trap Formulations in subjects with Neovascular Age Related Macular Degeneration (wet)
  • Regeneron Pharmaceuticals: VGFT-OD-0605 (VIEW 1) - Vascular Endothelial Growth Factor(VEGF)Trap-Eye:Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration(AMD)
  • Regeneron Pharmaceuticals: VGFT-OD-0702 - Randomized, Single-Masked, Long-Term, Safety and Tolerability Study of VEGF Trap-Eye in AMD
  • SCORE - The Standard Care vs. Corticosteroid (triamcinolone acetonide) for Retinal Vein Occlusion
  • Thrombogenics: TG-MV-007 (MIVI) - Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion
  • Thrombogenics- (TG-MV-014): A Randomized, Sham-controlled, Double-masked, Multicenter Study Evaluating Ocriplasmin Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole